T cell Reconstitution in Allogeneic Haematopoietic Stem Cell Transplantation: Prognostic Significance of Plasma Interleukin-7
نویسندگان
چکیده
منابع مشابه
IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantation.
We used clinically relevant murine allogeneic bone marrow transplantation (BMT) models to study the mechanisms by which IL-7 administration can improve posttransplant peripheral T cell reconstitution. After transplant we could distinguish two populations of mature donor T cells: (a) alloreactive T cells with decreased expression of CD127 (IL-7 receptor alpha chain) and (b) nonalloreactive T cel...
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Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in T-cell development and survival and enhances immune recovery in murine models of allo-HSCT. We performed a phase 1 trial of r-hIL-7 (CYT107) in recipients of T-cell depleted allo-HSCTs. Twelve patients were treate...
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Reported cases of subcutaneous panniculitis-like T-cell lymphoma (SPTL) show different clinical courses depending on the immunophenotype of the tumour cells. They can either express α and β or γ and δ polypeptide chains in the T-cell receptor (TCR). These differences caused the World Health Organization's European Organization for Research and Treatment of Cancer (WHO-EORTC) to classify this ty...
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Bronchiolitis obliterans (BO) following allogeneic haematopoietic stem cell transplantation (HSCT) affects peripheral airways. Detection of BO is presently delayed by the low sensitivity of spirometry. We examined the relationship between peripheral airway function and time since HSCT, and compared it with spirometry and clinical indices in 33 clinically stable allogeneic HSCT recipients. The f...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2014
ISSN: 0300-9475
DOI: 10.1111/sji.12244